ABSTRACT
Bacterial resistance is an increasingly serious problem.Therefore,it is necessary to find new antibacterial drugs.Flavonoids are a class of polyphenolic chemicals with low molecular weight,which exhibit many beneficial properties for human health by the interaction of cellular targets,such as the key cell signaling pathways.Flavonoids have been extensively studied as one of the important sources of antimicrobial compounds.At present,antibacterial flavonoids can be divided into two categories.One is the natural,extracted from the plant or microbial secondary metabolites.The other is the product of chemical synthesis,i.e.the derivatives of flavonoids or chalcone.In this paper,the progress of antibacterial flavonoids by natural extraction and chemical synthesis were summarized.
ABSTRACT
Bacterial resistance is an increasingly serious problem.Therefore,it is necessary to find new antibacterial drugs.Flavonoids are a class of polyphenolic chemicals with low molecular weight,which exhibit many beneficial properties for human health by the interaction of cellular targets,such as the key cell signaling pathways.Flavonoids have been extensively studied as one of the important sources of antimicrobial compounds.At present,antibacterial flavonoids can be divided into two categories.One is the natural,extracted from the plant or microbial secondary metabolites.The other is the product of chemical synthesis,i.e.the derivatives of flavonoids or chalcone.In this paper,the progress of antibacterial flavonoids by natural extraction and chemical synthesis were summarized.